Pre_GI: BLASTP Hits

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Query: NC_012943:2707677:2707677 Mycobacterium tuberculosis KZN 1435 chromosome, complete genome

Start: 2707677, End: 2708408, Length: 732

Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: M. tuberculosis strain KZN 1435 was isolated from a patient in KwaZulu-Natal, South Africa. This strain is multidrug-resistant (resistant to isoniazid and rifampin). This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. This species is responsible for more morbidity in humans than any other bacterial disease. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. The envelope contains the typical polypeptide layer, the peptidoglycan layer, and free lipids. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. These fatty acid-carbohydrate complexes inhibit phago-lysosome fusion and are often considered to be indicators of virulent strains. The cell envelope also includes adhesins and aggressions, but does not contain any known toxins. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017026:1686500:170609317060931706824732Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein1e-121435
NC_009565:1688642:170969517096951710426732Mycobacterium tuberculosis F11, complete genomehypothetical protein1e-121435
NC_002755:1684161:170521317052131705944732Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein1e-121435
NC_000962:1684005:170505817050581705789732Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein1e-121435
NC_009525:1685522:170657517065751707306732Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein1e-121435
NC_016768:2704350:270435027043502705081732Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein1e-121435
NC_015848:1708176:172923317292331729967735Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein9e-119426
NC_019950:1689910:170981817098181710552735Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein9e-119426
NC_015848:3343731:336528933652893366020732Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein7e-86316
NC_009565:3299937:332014133201413320872732Mycobacterium tuberculosis F11, complete genomehypothetical protein7e-86316
NC_000962:3288464:330866833086683309399732Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein7e-86316
NC_019950:3306419:332959833295983330329732Mycobacterium canettii CIPT 140060008 complete genomehypothetical protein7e-86316
NC_009525:3300456:332066033206603321391732Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein7e-86316
NC_002755:3282785:330298833029883303719732Mycobacterium tuberculosis CDC1551, complete genomehypothetical protein7e-86316
NC_017026:3282405:330261333026133303344732Mycobacterium tuberculosis RGTB327 chromosome, complete genomehypothetical protein7e-86316
NC_016804:3221818:324219432421943242925732Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein2e-85315
NC_012207:3237440:325565632556563256387732Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein2e-85315
NC_002945:3246278:326535632653563266087732Mycobacterium bovis AF2122/97, complete genomehypothetical protein2e-85315
NC_008769:3242453:326282932628293263560732Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein2e-85315
NC_002944:1285436:129571912957191296441723Mycobacterium avium subsp. paratuberculosis K-10, complete genomehypothetical protein5e-83307
NC_016604:297687:314531314531315271741Mycobacterium rhodesiae NBB3 chromosome, complete genomeFkbM family methyltransferase1e-82306
NC_016948:3381848:340316534031653403590426Mycobacterium intracellulare MOTT-64 chromosome, complete genomehypothetical protein4e-54211
NC_016947:3309898:333122333312233331606384Mycobacterium intracellulare MOTT-02 chromosome, complete genomehypothetical protein2e-48192
NC_015572:1252000:129141412914141292145732Methylomonas methanica MC09 chromosome, complete genomemethyltransferase FkbM family3e-44178
NC_007484:1671835:168403416840341684747714Nitrosococcus oceani ATCC 19707, complete genomeMethyltransferase FkbM1e-1893.6
NC_011901:2202690:222057222205722221300729Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completemethyltransferase FkbM3e-1788.6
NC_011901:2202690:223037822303782231085708Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completehypothetical protein6e-1684.3
NC_010475:1161000:117416311741631174906744Synechococcus sp. PCC 7002, complete genomemethyltransferase, FkbM family protein2e-1582.8
NC_008146:1016446:103992010399201040783864Mycobacterium sp. MCS, complete genomeMethyltransferase FkbM7e-1580.9
NC_008705:1022252:104565410456541046427774Mycobacterium sp. KMS, complete genomemethyltransferase FkbM family7e-1580.9
NC_002977:1198438:121289712128971213658762Methylococcus capsulatus str. Bath, complete genomemethyltransferase, FkbM family4e-1375.1
NC_011832:366092:374900374900375670771Candidatus Methanosphaerula palustris E1-9c, complete genomemethyltransferase FkbM family4e-0755.5
NC_016629:1111619:113694311369431137827885Desulfovibrio africanus str. Walvis Bay chromosome, completeFkbM family methyltransferase5e-0755.1
NC_017904:3415700:344746734474673447961495Mycobacterium sp. MOTT36Y chromosome, complete genomehypothetical protein5e-0755.1
NC_011666:3001513:3004912300491230059971086Methylocella silvestris BL2, complete genomemethyltransferase FkbM family7e-0754.3
NC_007508:2277640:228465422846542285406753Xanthomonas campestris pv. vesicatoria str. 85-10, complete genomehypothetical protein1e-0653.9
NC_008726:1776192:178661417866141787081468Mycobacterium vanbaalenii PYR-1, complete genome2e-0653.1
NC_009937:3324793:333558033355803336365786Azorhizobium caulinodans ORS 571, complete genomemethyltransferase2e-0653.1
NC_020541:625925:632216632216632980765Rhodanobacter sp. 2APBS1, complete genomemethyltransferase, FkbM family2e-0653.1
NC_013743:3020687:303259730325973033412816Haloterrigena turkmenica DSM 5511, complete genomemethyltransferase FkbM family3e-0652
NC_000914:135534:151051151051151782732Rhizobium sp. NGR234 plasmid pNGR234a, complete sequenceNoeI3e-0652
NC_017271:2278500:228450422845042285256753Xanthomonas campestris pv. raphani 756C chromosome, completemethyltransferase, FkbM family protein3e-0652