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Query: NC_012659:678289:694447 Bacillus anthracis str. A0248, complete genome

Start: 694447, End: 694791, Length: 345

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:657568:675550675550675894345Bacillus cereus F837/76 chromosome, complete genomePotassium channel protein2e-43174
NC_016771:701909:721795721795722139345Bacillus cereus NC7401, complete genomehypothetical protein2e-43174
NC_005957:667954:685429685429685773345Bacillus thuringiensis serovar konkukian str. 97-27, completeconserved hypothetical protein, possible potassium channel protein2e-43174
NC_011969:726369:743849743849744193345Bacillus cereus Q1 chromosome, complete genomepotassium channel protein2e-42171
NC_011725:681387:698425698425698769345Bacillus cereus B4264 chromosome, complete genomehypothetical protein3e-42170
NC_004722:650950:667987667987668331345Bacillus cereus ATCC 14579, complete genomePotassium channel protein3e-42170
NC_010184:661226:679912679912680256345Bacillus weihenstephanensis KBAB4, complete genomeIon transport 2 domain protein6e-42169
NC_011772:647778:666704666704667048345Bacillus cereus G9842, complete genomehypothetical protein6e-42169