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Query: NC_012659:4853640:4855324 Bacillus anthracis str. A0248, complete genome

Start: 4855324, End: 4856304, Length: 981

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012581:4856620:485774748577474858727981Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein0660
NC_005945:4854951:485663548566354857615981Bacillus anthracis str. Sterne, complete genomehypothetical protein0660
NC_003997:4852332:485529848552984856278981Bacillus anthracis str. Ames, complete genomehypothetical protein0660
NC_007530:4853740:485542448554244856404981Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein0660
NC_014171:4933200:4934512493451249362451734Bacillus thuringiensis BMB171 chromosome, complete genomephage prohead protease6e-1065.5
NC_003997:4852332:4854171485417148552111041Bacillus anthracis str. Ames, complete genomephage major capsid protein, HK97 family3e-0963.2
NC_007530:4853740:4854297485429748553371041Bacillus anthracis str. 'Ames Ancestor', complete genomephage major capsid protein, hk97 family3e-0963.2
NC_012581:4856620:4856620485662048576601041Bacillus anthracis str. CDC 684 chromosome, complete genomephage major capsid protein, HK97 family3e-0963.2
NC_012659:4853640:4854197485419748552371041Bacillus anthracis str. A0248, complete genomephage major capsid protein, HK97 family3e-0963.2
NC_005945:4854951:4855469485546948565481080Bacillus anthracis str. Sterne, complete genomephage major capsid protein, HK97 family2e-0963.2
NC_007432:654904:6841946841946854021209Streptococcus agalactiae A909, complete genomeprophage LambdaSa04, major capsid protein, HK97 family2e-0756.6
NC_015697:506494:5281265281265293041179Lactobacillus reuteri SD2112 chromosome, complete genomeHK97 family major capsid protein7e-0651.6