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Query: NC_012659:4674235:4691120 Bacillus anthracis str. A0248, complete genome

Start: 4691120, End: 4692775, Length: 1656

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005945:4670978:4688007468800746940846078Bacillus anthracis str. Sterne, complete genomecell surface protein, gram positive anchor01035
NC_014335:4622500:4637099463709946452738175Bacillus cereus biovar anthracis str. CI chromosome, completeputative cell surface protein0964
NC_006274:4742489:47570794757079476749710419Bacillus cereus E33L, complete genomecell surface protein0961
NC_011725:4870223:48778554877855488808410230Bacillus cereus B4264 chromosome, complete genomecell surface protein0941
NC_011773:4732457:47470494747049475761410566Bacillus cereus AH820 chromosome, complete genomehypothetical protein0917
NC_005957:4680089:46930514693051470346610416Bacillus thuringiensis serovar konkukian str. 97-27, completeconserved hypothetical protein, possible cell surface anchor0913
NC_016779:4645155:46596944659694467022910536Bacillus cereus F837/76 chromosome, complete genomeCell surface protein0907
NC_008600:4687500:47020714702071471283710767Bacillus thuringiensis str. Al Hakam, complete genomepossible cell surface anchor0907
NC_012472:4691251:47057904705790471607610287Bacillus cereus 03BB102, complete genomecell surface protein0906
NC_017200:4697500:47115924711592472229510704Bacillus thuringiensis serovar finitimus YBT-020 chromosome,cell surface protein0896
NC_004722:4824818:48378464837846484796710122Bacillus cereus ATCC 14579, complete genomeCell surface protein0889
NC_014171:4740500:4753927475392747632959369Bacillus thuringiensis BMB171 chromosome, complete genomecell surface protein0745
NC_017316:1840462:1846772184677218524685697Enterococcus faecalis OG1RF chromosome, complete genomecell wall surface anchor family protein7e-0859.3