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Query: NC_012659:4674235:4675508 Bacillus anthracis str. A0248, complete genome

Start: 4675508, End: 4676101, Length: 594

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003997:4674209:467548246754824676075594Bacillus anthracis str. Ames, complete genomebioY family protein2e-78291
NC_007530:4674335:467560846756084676201594Bacillus anthracis str. 'Ames Ancestor', complete genomebioy family protein2e-78291
NC_005945:4670978:467670546767054677298594Bacillus anthracis str. Sterne, complete genomebioY family protein2e-78291
NC_014335:4622500:462684146268414627434594Bacillus cereus biovar anthracis str. CI chromosome, completebiotin synthesis BioY protein4e-78290
NC_017200:4697500:470136047013604701953594Bacillus thuringiensis serovar finitimus YBT-020 chromosome,bioY family protein2e-77288
NC_006274:4742489:474682247468224747415594Bacillus cereus E33L, complete genomebiotin synthesis BioY protein1e-77288
NC_008600:4687500:469186646918664692459594Bacillus thuringiensis str. Al Hakam, complete genomebiotin synthesis protein1e-77288
NC_012472:4691251:469558546955854696178594Bacillus cereus 03BB102, complete genomebioY family protein1e-77288
NC_016779:4645155:464948946494894650082594Bacillus cereus F837/76 chromosome, complete genomeECF transporter substrate-specific protein BioY1e-77288
NC_005957:4680089:468088346808834681476594Bacillus thuringiensis serovar konkukian str. 97-27, completebiotin synthesis BioY protein4e-77287
NC_011773:4732457:473679147367914737384594Bacillus cereus AH820 chromosome, complete genomebioY family protein4e-77287
NC_011969:4613430:461776746177674618360594Bacillus cereus Q1 chromosome, complete genomebioy family protein1e-76285
NC_011658:4672000:467635646763564676949594Bacillus cereus AH187 chromosome, complete genomebioY family protein1e-76285
NC_014171:4740500:474345347434534744046594Bacillus thuringiensis BMB171 chromosome, complete genomeBioY protein8e-76282
NC_004722:4824818:482758048275804828101522Bacillus cereus ATCC 14579, complete genomeBioY protein9e-68256
NC_021182:162236:164845164845165411567Clostridium pasteurianum BC1, complete genomehypothetical protein2e-0858.5
NC_014643:2056280:211902121190212119614594Rothia dentocariosa ATCC 17931 chromosome, complete genomeBioY family protein8e-0857
NC_020291:2701149:271249927124992713050552Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein5e-0651.2
NC_000961:135493:138195138195138683489Pyrococcus horikoshii OT3, complete genomehypothetical protein1e-0550.1