Pre_GI: BLASTP Hits

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Query: NC_012659:3692803:3698775 Bacillus anthracis str. A0248, complete genome

Start: 3698775, End: 3699086, Length: 312

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012581:519969:539501539501539812312Bacillus anthracis str. CDC 684 chromosome, complete genomehaloacid dehalogenase-like family hydrolase7e-55212
NC_005945:3693471:369944336994433699754312Bacillus anthracis str. Sterne, complete genomehypothetical protein7e-55212
NC_011969:3627980:363128336312833631960678Bacillus cereus Q1 chromosome, complete genomehaloacid dehalogenase4e-53206
NC_017208:3897253:390055639005563901233678Bacillus thuringiensis serovar chinensis CT-43 chromosome, completephosphoglycolate phosphatase3e-52202
NC_005957:3716487:372094437209443721621678Bacillus thuringiensis serovar konkukian str. 97-27, completehydrolase, haloacid dehalogenase-like family6e-51199
NC_017200:3737185:374361737436173744294678Bacillus thuringiensis serovar finitimus YBT-020 chromosome,HAD superfamily hydrolase6e-49192
NC_012472:3743473:374677437467743747451678Bacillus cereus 03BB102, complete genomehydrolase, haloacid dehalogenase-like family6e-43172
NC_016779:3660000:366460636646063665283678Bacillus cereus F837/76 chromosome, complete genome2-haloalkanoic acid dehalogenase6e-43172
NC_011658:3680829:368737836873783688001624Bacillus cereus AH187 chromosome, complete genomeHAD superfamily hydrolase8e-34142
NC_003552:1492500:149289714928971493604708Methanosarcina acetivorans C2A, complete genomehaloacid dehalogenase-like hydrolase family protein6e-1682.8
NC_011899:12699:310733107331786714Halothermothrix orenii H 168, complete genomeHAD-superfamily hydrolase, subfamily IA, variant 13e-1270.5
NC_014550:3263783:326643532664353267112678Arthrobacter arilaitensis Re117, complete genomehaloacid dehalogenase-like family hydrolase4e-0753.5