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Query: NC_012659:3579999:3594632 Bacillus anthracis str. A0248, complete genome

Start: 3594632, End: 3595417, Length: 786

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:3622838:363636536363653637150786Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein1e-152538
NC_003997:3579972:359460535946053595390786Bacillus anthracis str. Ames, complete genomeACT domain protein1e-152538
NC_005957:3602744:361627436162743617059786Bacillus thuringiensis serovar konkukian str. 97-27, completeconserved hypothetical protein, possible ACT domain protein1e-152538
NC_006274:3661194:367515736751573675942786Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible ACT domain protein1e-152538
NC_012472:3625800:363943636394363640221786Bacillus cereus 03BB102, complete genomeACT domain protein1e-152538
NC_008600:3611038:362142936214293622214786Bacillus thuringiensis str. Al Hakam, complete genomepossible ACT domain protein1e-152538
NC_011772:3705878:372304437230443723829786Bacillus cereus G9842, complete genomeACT domain protein1e-152538
NC_005945:3581776:359530635953063596091786Bacillus anthracis str. Sterne, complete genomeACT domain protein1e-152538
NC_014335:3531931:354545435454543546239786Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein1e-152538
NC_007530:3581202:359473235947323595517786Bacillus anthracis str. 'Ames Ancestor', complete genomeact domain protein1e-152538
NC_011725:3785769:379940537994053800190786Bacillus cereus B4264 chromosome, complete genomeACT domain-containing protein1e-152538
NC_011773:3615998:362952736295273630312786Bacillus cereus AH820 chromosome, complete genomeACT domain-containing protein1e-152538
NC_012581:639329:643171643171643956786Bacillus anthracis str. CDC 684 chromosome, complete genomeACT domain-containing protein1e-152538
NC_014171:3661512:367866836786683679453786Bacillus thuringiensis BMB171 chromosome, complete genomeACT domain-containing protein1e-152538
NC_016771:3520522:353517135351713535956786Bacillus cereus NC7401, complete genomeACT domain-containing protein1e-152538
NC_011899:948790:948790948790949557768Halothermothrix orenii H 168, complete genomeamino acid-binding ACT domain protein9e-52203