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Query: NC_012659:2175867:2176498 Bacillus anthracis str. A0248, complete genome

Start: 2176498, End: 2176710, Length: 213

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011773:2239753:224038722403872240599213Bacillus cereus AH820 chromosome, complete genomehypothetical protein6e-26116
NC_012472:2240000:224021522402152240427213Bacillus cereus 03BB102, complete genomehypothetical protein6e-26115
NC_014171:2177353:217898821789882179200213Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein7e-25112
NC_014335:2151404:215267721526772152937261Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein6e-26115
NC_011658:2275864:227586422758642276076213Bacillus cereus AH187 chromosome, complete genomehypothetical protein9e-26115
NC_007530:2175967:217659821765982176810213Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein6e-26116
NC_005957:2196000:219603121960312196300270Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-26115
NC_011772:2166000:216608021660802166292213Bacillus cereus G9842, complete genomehypothetical protein1e-24112
NC_003997:2175843:217647421764742176686213Bacillus anthracis str. Ames, complete genomehypothetical protein6e-26116
NC_005945:2175871:217644521764452176714270Bacillus anthracis str. Sterne, complete genomehypothetical protein6e-26115
NC_011725:2206000:220680522068052207017213Bacillus cereus B4264 chromosome, complete genomehypothetical protein7e-25112