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Query: NC_012659:1008028:1023221 Bacillus anthracis str. A0248, complete genome

Start: 1023221, End: 1023586, Length: 366

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016779:991298:100505110050511005416366Bacillus cereus F837/76 chromosome, complete genomehypothetical protein3e-51199
NC_011773:1050000:106554110655411065906366Bacillus cereus AH820 chromosome, complete genomehypothetical protein3e-51199
NC_007530:1007140:102332110233211023686366Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein3e-51199
NC_003997:1007139:102332110233211023686366Bacillus anthracis str. Ames, complete genomehypothetical protein3e-51199
NC_005945:1008000:102321410232141023579366Bacillus anthracis str. Sterne, complete genomehypothetical protein3e-51199
NC_006274:1040836:105623310562331056598366Bacillus cereus E33L, complete genomehypothetical protein7e-51198
NC_005957:1037205:105256710525671052932366Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-50197
NC_016935:1365463:137983513798351380191357Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein4e-1477
NC_015690:3941113:395302339530233953379357Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein2e-1374.3
NC_011894:6731115:673111567311156731516402Methylobacterium nodulans ORS 2060, complete genomeDoxX family protein6e-1062.8