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Query: NC_012659:1008028:1019525 Bacillus anthracis str. A0248, complete genome

Start: 1019525, End: 1019935, Length: 411

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011773:1050000:106183010618301062240411Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-64243
NC_005945:1008000:101951810195181019928411Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-64243
NC_003997:1007139:101962510196251020035411Bacillus anthracis str. Ames, complete genomehypothetical protein2e-64243
NC_007530:1007140:101962510196251020035411Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-64243
NC_017200:1157835:117265411726541173064411Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein9e-63238
NC_016779:991298:100066110006611001071411Bacillus cereus F837/76 chromosome, complete genomehypothetical protein1e-54211
NC_008600:1042477:105409110540911054513423Bacillus thuringiensis str. Al Hakam, complete genomehypothetical protein1e-54211
NC_005957:1037205:104834710483471048604258Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein5e-35145
NC_005957:1037205:104818110481811048375195Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein2e-1374.7
NC_011969:1084000:109424710942471094414168Bacillus cereus Q1 chromosome, complete genomehypothetical protein4e-0650.4