Pre_GI: BLASTP Hits

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Query: NC_012658:545840:551343 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 551343, End: 552119, Length: 777

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016584:1912000:191228419122841913102819Desulfosporosinus orientis DSM 765 chromosome, complete genomehypothetical protein3e-50198
NC_012658:2138791:215738021573802158195816Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-47189
NC_017297:2143000:216090821609082161723816Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-47189
NC_009699:2142177:216080821608082161623816Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-47189
NC_009495:2085000:210265421026542103469816Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein3e-47188
NC_009697:2012500:203129520312952032110816Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-47188
NC_009698:2012500:203151420315142032329816Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein3e-47188
NC_010516:2093901:211056521105652111380816Clostridium botulinum B1 str. Okra, complete genomeputative protein of unknown function3e-47188
NC_012563:2230403:224931022493102250125816Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-46186
NC_014614:86213:906169061691434819Clostridium sticklandii, complete genomehypothetical protein4e-44178
NC_019977:728922:741895741895742581687Methanomethylovorans hollandica DSM 15978, complete genomehypothetical protein2e-22106
NC_009051:930758:952286952286953002717Methanoculleus marisnigri JR1, complete genomeprotein of unknown function DUF1696e-2097.8
NC_013790:756000:769318769318769977660Methanobrevibacter ruminantium M1 chromosome, complete genomehypothetical protein7e-1890.9
NC_018876:2628966:263393426339342634626693Methanolobus psychrophilus R15 chromosome, complete genomehypothetical protein1e-1790.1
NC_009635:800000:803526803526804209684Methanococcus aeolicus Nankai-3 chromosome, complete genomehypothetical protein5e-1788.2
NC_013156:1240926:126027412602741260966693Methanocaldococcus fervens AG86, complete genomeprotein of unknown function DUF1693e-1685.5
NC_009635:518000:524689524689525372684Methanococcus aeolicus Nankai-3 chromosome, complete genomehypothetical protein6e-1684.7
NC_018870:115982:1204311204311214381008Thermacetogenium phaeum DSM 12270 chromosome, complete genomehypothetical protein3e-0962
NC_007681:1455425:145542514554251456024600Methanosphaera stadtmanae DSM 3091, complete genomehypothetical protein7e-0857.8
NC_015573:2900906:291732129173212918142822Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehypothetical protein8e-0857.4