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Query: NC_012658:35500:54940 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 54940, End: 56382, Length: 1443

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:33519:5617456174576161443Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein0803
NC_009699:33452:5604156041574831443Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein0803
NC_010516:42475:6098460984624261443Clostridium botulinum B1 str. Okra, complete genomehypothetical protein0803
NC_010520:35845:5498854988564301443Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein0800
NC_012563:36000:5520055200566421443Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0798
NC_009495:38000:6109261092625341443Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein0795
NC_009697:38000:6095360953623951443Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein0795
NC_009698:38000:6095460954623961443Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein0795
NC_015172:1429266:1448011144801114494531443Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomehypothetical protein4e-121435
NC_009495:1759759:1763847176384717653011455Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-73275
NC_004557:691944:7069317069317080311101Clostridium tetani E88, complete genomehypothetical protein2e-1377.8
NC_010723:1133163:1133719113371911347891071Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein4e-0860.1