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Query: NC_012658:35500:39974 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 39974, End: 41083, Length: 1110

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009495:38000:4596045960470931134Clostridium botulinum A str. ATCC 3502 chromosome, complete genomemajor facilitator superfamily protein4e-148524
NC_017297:33519:4140941409425181110Clostridium botulinum F str. 230613 chromosome, complete genomemajor facilitator superfamily protein7e-148523
NC_009699:33452:4134141341424501110Clostridium botulinum F str. Langeland chromosome, complete genomemajor facilitator superfamily protein7e-148523
NC_009698:38000:4599945999471081110Clostridium botulinum A str. Hall chromosome, complete genomemajor facilitator superfamily protein7e-148523
NC_009697:38000:4599945999471081110Clostridium botulinum A str. ATCC 19397 chromosome, completemajor facilitator superfamily protein7e-148523
NC_012563:36000:4039840398415071110Clostridium botulinum A2 str. Kyoto, complete genomemajor facilitator superfamily protein7e-148523
NC_010520:35845:4019040190412991110Clostridium botulinum A3 str. Loch Maree, complete genomemajor facilitator superfamily protein2e-147522
NC_010516:42475:4607546075471841110Clostridium botulinum B1 str. Okra, complete genomemajor facilitator superfamily protein6e-147520
NC_008593:2457594:2493438249343824946161179Clostridium novyi NT, complete genomeMajor Facilitator Superfamily protein1e-65250
NC_015425:2690448:2727546272754627286491104Clostridium botulinum BKT015925 chromosome, complete genomemajor facilitator superfamily protein8e-64244
NC_008262:67711:7218672186733611176Clostridium perfringens SM101, complete genometransporter, putative4e-54212
NC_003366:64908:6939969399705651167Clostridium perfringens str. 13, complete genomehypothetical protein5e-54211
NC_008261:64678:6917069170703361167Clostridium perfringens ATCC 13124, complete genomemajor facilitator family transporter5e-54211
NC_021182:4058873:4058873405887340600871215Clostridium pasteurianum BC1, complete genomefucose permease2e-48193
NC_021182:4058873:4069005406900540701741170Clostridium pasteurianum BC1, complete genomefucose permease3e-43176