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Query: NC_012658:35500:38643 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 38643, End: 38804, Length: 162

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:33519:400784007840239162Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein6e-2199.4
NC_010520:35845:388593885939020162Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein6e-2199.4
NC_010516:42475:447444474444905162Clostridium botulinum B1 str. Okra, complete genomehypothetical protein6e-2199.4
NC_012563:36000:390673906739228162Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein6e-2199.4
NC_009697:38000:446684466844829162Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein6e-2199.4
NC_009698:38000:446684466844829162Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein6e-2199.4
NC_009699:33452:400104001040171162Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein6e-2199.4
NC_015425:2690448:273015127301512730330180Clostridium botulinum BKT015925 chromosome, complete genomehypothetical protein8e-0855.8
NC_021182:93000:111393111393111554162Clostridium pasteurianum BC1, complete genomehypothetical protein3e-0650.8
NC_014393:92500:105481105481105654174Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein6e-0649.3