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Query: NC_012658:3387774:3408767 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 3408767, End: 3409360, Length: 594

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:3185359:320200032020003202590591Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein7e-98356
NC_009697:3291500:330489333048933305483591Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein7e-98356
NC_009495:3309550:332890433289043329494591Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein7e-98356
NC_012563:3556763:357098335709833571573591Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-98356
NC_010516:3368951:338932733893273389917591Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-97354
NC_014328:3747973:376091637609163761515600Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein5e-37154
NC_011898:189498:196730196730197167438Clostridium cellulolyticum H10, complete genomeprotein of unknown function DUF7102e-1065.5
NC_003366:2143173:2163776216377621651311356Clostridium perfringens str. 13, complete genomehypothetical protein4e-1064.7
NC_014657:291567:309159309159309632474Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein8e-0960.1
NC_020291:1149887:1156724115672411586461923Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomecell division protein ZapA1e-0859.3
NC_006270:2886193:289097128909712891228258Bacillus licheniformis ATCC 14580, complete genomeZapA6e-0650.8
NC_006322:2886404:289118228911822891439258Bacillus licheniformis ATCC 14580, complete genomeYshA6e-0650.8