Pre_GI: BLASTP Hits

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Query: NC_012658:3126108:3129440 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 3129440, End: 3129844, Length: 405

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010520:3120500:312511131251113125515405Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein9e-71265
NC_012563:3288124:329164232916423292046405Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-70263
NC_009698:2921097:292448529244852924889405Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein5e-68255
NC_009697:2984173:298756129875612987965405Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein5e-68255
NC_009495:3051223:305461130546113055015405Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein5e-68255
NC_012563:2597934:259954025995402599905366Clostridium botulinum A2 str. Kyoto, complete genomephage protein5e-2096.3
NC_009495:1821938:183530418353041835678375Clostridium botulinum A str. ATCC 3502 chromosome, complete genomephage protein3e-1167
NC_010674:2856997:286191328619132862206294Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-0754.7