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Query: NC_012658:2584355:2598947 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2598947, End: 2599219, Length: 273

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003909:3587695:358943135894313589682252Bacillus cereus ATCC 10987, complete genomehypothetical protein8e-0649.3
NC_014328:1405484:142172414217241421996273Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein2e-25114
NC_017200:3655496:365843036584303658681252Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein8e-0649.3
NC_010520:2585014:260350526035052603777273Clostridium botulinum A3 str. Loch Maree, complete genomePRC-barrel domain protein3e-44176
NC_012563:2680246:271526327152632715535273Clostridium botulinum A2 str. Kyoto, complete genomePRC-barrel domain protein3e-44176
NC_010516:2511035:252897425289742529246273Clostridium botulinum B1 str. Okra, complete genomePRC-barrel domain protein3e-44176
NC_008261:2157713:217109721710972171372276Clostridium perfringens ATCC 13124, complete genomePRC-barrel domain protein4e-2096.7
NC_008262:1835613:184514518451451845420276Clostridium perfringens SM101, complete genomePRC-barrel domain protein4e-2096.7
NC_009697:2394826:241277424127742413046273Clostridium botulinum A str. ATCC 19397 chromosome, completePRC-barrel domain-containing protein3e-44176
NC_009698:2367171:238511923851192385391273Clostridium botulinum A str. Hall chromosome, complete genomePRC-barrel domain-containing protein3e-44176
NC_009699:2576500:258948825894882589760273Clostridium botulinum F str. Langeland chromosome, complete genomePRC-barrel domain-containing protein8e-44175
NC_009495:2524000:254075125407512541023273Clostridium botulinum A str. ATCC 3502 chromosome, complete genomePRC-barrel domain-containing protein3e-44176
NC_020291:1464500:147992014799201480201282Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomesporulation protein, YlmC/YmxH family1e-22105
NC_017297:2575306:258962825896282589900273Clostridium botulinum F str. 230613 chromosome, complete genomeYlmC/YmxH family sporulation protein8e-44175