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Query: NC_012658:2584355:2596807 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2596807, End: 2597487, Length: 681

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:2394826:241061324106132411305693Clostridium botulinum A str. ATCC 19397 chromosome, completeClp protease9e-126449
NC_009495:2524000:253859025385902539282693Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeClp protease9e-126449
NC_009698:2367171:238295823829582383650693Clostridium botulinum A str. Hall chromosome, complete genomeClp protease9e-126449
NC_012563:2680246:271310227131022713794693Clostridium botulinum A2 str. Kyoto, complete genomeClp protease family protein9e-126449
NC_010520:2585014:260134326013432602035693Clostridium botulinum A3 str. Loch Maree, complete genomeclp protease9e-126449
NC_010516:2511035:252681325268132527505693Clostridium botulinum B1 str. Okra, complete genomeclp protease2e-125447
NC_017297:2575306:258746725874672588159693Clostridium botulinum F str. 230613 chromosome, complete genomeclp protease9e-126449
NC_009699:2576500:258732725873272588019693Clostridium botulinum F str. Langeland chromosome, complete genomeClp protease9e-126449
NC_014328:1405484:142210314221031422768666Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative protease4e-91333
NC_008261:2157713:216914421691442169833690Clostridium perfringens ATCC 13124, complete genomeclp protease1e-83309
NC_008262:1835613:184319218431921843881690Clostridium perfringens SM101, complete genomeclp protease1e-83308
NC_020291:1464500:148150414815041482211708Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genometranslocation-enhancing protein TepA5e-85313
NC_020134:1243122:125473112547311255489759Clostridium stercorarium subsp. stercorarium DSM 8532, completetranslocation-enhancing protein TepA2e-78291
NC_015573:2463123:249884024988402499355516Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomepeptidase S14 ClpP2e-35149