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Query: NC_012658:2525931:2536794 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2536794, End: 2537750, Length: 957

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015660:739040:748842748842749696855Geobacillus thermoglucosidasius C56-YS93 chromosome, completeprimosome, DnaD subunit6e-49194
NC_018704:176088:1952841952841963331050Amphibacillus xylanus NBRC 15112, complete genomehypothetical protein6e-49194
NC_020272:1311932:132471213247121325584873Bacillus amyloliquefaciens IT-45, complete genomeDnaA like protein, DnaD domain protein3e-48192
NC_009089:1093832:109920010992001100039840Clostridium difficile 630, complete genomephage protein5e-47188
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome2e-46186
NC_013171:896802:902461902461903405945Anaerococcus prevotii DSM 20548, complete genomehypothetical protein7e-23108
NC_006582:2944237:298357029835702984349780Bacillus clausii KSM-K16, complete genomephage replication protein1e-1997.4
NC_014657:914071:914071914071915021951Caldicellulosiruptor owensensis OL chromosome, complete genomehypothetical protein1e-1687.4
NC_010674:2856997:286452928645292865350822Clostridium botulinum B str. Eklund 17B, complete genomereplication initiation protein1e-0963.9
NC_007759:1169547:119113311911331191918786Syntrophus aciditrophicus SB, complete genomephage replication protein3e-0652.8