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Query: NC_012658:2525931:2534752 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2534752, End: 2535747, Length: 996

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009495:2479465:251258125125812513534954Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeRNA polymerase sigma factor2e-160565
NC_014639:2169277:217149621714962172224729Bacillus atrophaeus 1942 chromosome, complete genomesporulation sigma factor SigK2e-1170.5
CP002207:2169277:217149621714962172224729Bacillus atrophaeus 1942, complete genomesporulation sigma factor SigK2e-1170.5
UCMB5137:2054735:206023320602332060961729Bacillus atrophaeus UCMB-5137sporulation sigma factor SigK2e-1170.5
NC_020291:1389114:139256713925671393274708Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeRNA polymerase sigma-E factor SigE2e-1170.1
NC_016047:2631511:263408426340842634812729Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeRNA polymerase sigma-K factor2e-1170.1
NC_014479:2505823:250902725090272509755729Bacillus subtilis subsp. spizizenii str. W23 chromosome, completesporulation sigma factor SigmaK2e-1170.1
NC_017195:2498113:250061925006192501347729Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completeRNA polymerase sigma-K factor2e-1170.1
NC_017188:2512357:251601825160182516743726Bacillus amyloliquefaciens TA208 chromosome, complete genomesporulation sigma factor SigK2e-1170.1
NC_017191:2514401:251805925180592518787729Bacillus amyloliquefaciens XH7 chromosome, complete genomesporulation sigma factor SigK2e-1170.1
NC_006322:2658587:266257426625742663299726Bacillus licheniformis ATCC 14580, complete genomeSpoIIIC2e-1170.1
NC_006270:2657726:266171326617132662438726Bacillus licheniformis ATCC 14580, complete genomeRNA polymerase sporulation-specific sigma factor (sigma-K) (C-terminal half)2e-1170.1
NC_009725:2517428:252185025218502522572723Bacillus amyloliquefaciens FZB42, complete genomeSpoIIIC2e-1169.7
NC_020410:2509057:251185125118512512573723Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeRNA polymerase sigma-K factor2e-1169.7
NC_014551:2510000:251515725151572515879723Bacillus amyloliquefaciens DSM 7, complete genomeRNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)2e-1169.7
NC_020272:1384525:140054414005441401266723Bacillus amyloliquefaciens IT-45, complete genomesporulation sigma factor SigK2e-1169.7
NC_008346:584305:613841613841614575735Syntrophomonas wolfei subsp. wolfei str. Goettingen, completesigma 28 (flagella/sporulation)6e-1168.6
NC_019978:2036779:205421120542112054906696Halobacteroides halobius DSM 5150, complete genomeRNA polymerase sigma-K factor9e-1167.8
NC_011969:3627980:365406836540683654787720Bacillus cereus Q1 chromosome, complete genomesporulation sigma factor sige3e-1066.6
NC_014220:837926:841866841866842591726Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeRNA polymerase, sigma 28 subunit, FliA/WhiG subfamily7e-1065.1
NC_012654:170956:184629184629185513885Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceputative RNA polymerase sigma factor6e-0962
NC_007644:1603696:161628816162881616968681Moorella thermoacetica ATCC 39073, complete genomesigma 28 (Flagella/Sporulation)1e-0860.5
NC_017177:192933:210132210132210779648Clostridium difficile BI1, complete genomeSporulation sigma factor SigK2e-0860.1
NC_011969:3627980:365313136531313654000870Bacillus cereus Q1 chromosome, complete genomesporulation sigma factor sigg7e-0858.5
NC_017297:2531750:256721125672112567762552Clostridium botulinum F str. 230613 chromosome, complete genomesigma-70 family RNA polymerase sigma factor2e-0757.4
NC_009699:2552195:256707225670722567623552Clostridium botulinum F str. Langeland chromosome, complete genomesigma-70 family RNA polymerase sigma factor2e-0757.4
NC_014328:1307490:132611813261181326819702Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative RNA polymerase sigma-K factor4e-0755.8
NC_009633:760872:765332765332765904573Alkaliphilus metalliredigens QYMF chromosome, complete genomeECF subfamily RNA polymerase sigma-24 factor3e-0653.1
NC_014657:673500:688886688886689614729Caldicellulosiruptor owensensis OL chromosome, complete genomeRNA polymerase, sigma 28 subunit, flia/whig subfamily5e-0652.4