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Query: NC_012658:2498087:2517088 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2517088, End: 2517702, Length: 615

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2566500:258376025837602584374615Clostridium botulinum A2 str. Kyoto, complete genomephage scaffold protein4e-85313
NC_009495:2479465:249602524960252496639615Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein3e-77287
NC_014328:3434478:345017834501783450849672Clostridium ljungdahlii ATCC 49587 chromosome, complete genomephage-like protein3e-29127
NC_014551:576000:600313600313600978666Bacillus amyloliquefaciens DSM 7, complete genomescaffold protein gp201e-1686.3
NC_012658:1810640:183329418332941833899606Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative scaffold protein1e-1479.3
NC_017297:2531750:254694125469412547546606Clostridium botulinum F str. 230613 chromosome, complete genomephage minor structural protein GP208e-1477
NC_021182:3347076:336061233606123361196585Clostridium pasteurianum BC1, complete genomePhage minor structural protein GP201e-1376.3
NC_013517:1501276:150498315049831505585603Sebaldella termitidis ATCC 33386, complete genomeminor structural GP20 protein2e-1375.5
NC_015913:117966:138385138385138984600Candidatus Arthromitus sp. SFB-mouse-Japan, complete genomephage scaffold protein3e-1065.1
NC_017294:115500:137695137695138294600Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomephage minor structural protein GP203e-1065.1
NC_017294:403422:413852413852414451600Candidatus Arthromitus sp. SFB-mouse-Yit, complete genomeminor structural GP20 protein2e-0962.4
NC_011898:3824000:383985938398593840440582Clostridium cellulolyticum H10, complete genomeminor structural GP20 protein1e-0859.7
NC_020134:420500:437505437505438083579Clostridium stercorarium subsp. stercorarium DSM 8532, completeminor structural GP20 protein1e-0859.7
NC_011898:3567761:359143435914343592015582Clostridium cellulolyticum H10, complete genomeminor structural GP20 protein1e-0859.7
NC_021182:554000:577559577559578134576Clostridium pasteurianum BC1, complete genomePhage minor structural protein GP201e-0756.2
NC_015519:1081539:110206111020611102627567Tepidanaerobacter sp. Re1 chromosome, complete genomeminor structural GP20 protein2e-0755.5