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Query: NC_012658:2498087:2515609 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2515609, End: 2516661, Length: 1053

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2566500:2582281258228125833331053Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein0701
NC_009495:2479465:2494552249455224956041053Clostridium botulinum A str. ATCC 3502 chromosome, complete genomephage capsid protein0682
NC_014328:3434478:3448779344877934498161038Clostridium ljungdahlii ATCC 49587 chromosome, complete genomephage-like protein2e-88325
NC_003485:1061344:1061344106134410624231080Streptococcus pyogenes MGAS8232, complete genomehypothetical protein9e-30131
NC_012471:1752483:1759635175963517606841050Streptococcus equi subsp. equi 4047, complete genomephage capsid protein9e-30131
NC_011375:1457773:1479903147990314809851083Streptococcus pyogenes NZ131 chromosome, complete genomephage protein1e-26120
NC_014554:2159782:2159782215978221608041023Lactobacillus plantarum subsp. plantarum ST-III chromosome,prophage major head protein1e-1584.7