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Query: NC_012658:2498087:2503642 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2503642, End: 2504736, Length: 1095

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009697:3110772:3112540311254031136251086Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-109394
NC_013411:597235:6308896308896320341146Geobacillus sp. Y412MC61, complete genomephage related protein1e-90333
NC_014915:2963500:2971901297190129730461146Geobacillus sp. Y412MC52 chromosome, complete genomephage related protein1e-90333
NC_021184:4493440:4515106451510645162031098Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein1e-74280
NC_017297:3428429:343306934330693433992924Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-70267
NC_009699:3429817:343445734344573435380924Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-70267
NC_015519:2489728:2505513250551325066101098Tepidanaerobacter sp. Re1 chromosome, complete genomephage-like protein1e-67257
NC_009697:2558286:256284625628462563724879Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein2e-65249
NC_010516:2676746:268127826812782682156879Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-64246
NC_018515:4660808:4669065466906546701561092Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein8e-59227
NC_012563:2925472:2932346293234629335031158Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-53208
NC_016935:1636278:1676532167653216776591128Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein1e-52207
NC_010516:2305110:2314373231437323155301158Clostridium botulinum B1 str. Okra, complete genomehypothetical protein1e-52206
NC_015690:1186545:1227082122708212282091128Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein5e-52205
NC_017297:2017000:2019917201991720210741158Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein1e-50200
NC_009699:2017329:2019812201981220209691158Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-50200
NC_014393:2868846:2877234287723428783371104Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein2e-47189
NC_012563:2101449:2107992210799221091491158Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-44180
NC_016048:3899878:3919211391921139211271917Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein2e-32139
NC_016791:4038069:4050329405032940522691941Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein2e-31137
NC_011837:2605409:2636637263663726385591923Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-31136
NC_009706:2673906:2705134270513427070501917Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-31136
NC_021184:4456904:446441044644104464634225Desulfotomaculum gibsoniae DSM 7213, complete genome2e-1170.5
NC_009380:581000:6036316036316051001470Salinispora tropica CNB-440 chromosome, complete genomehypothetical protein2e-1067.4