Pre_GI: BLASTP Hits

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Query: NC_012658:2498087:2499363 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2499363, End: 2500208, Length: 846

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:1704345:172036117203611721119759Clostridium botulinum A2 str. Kyoto, complete genomebacteriophage endolysin2e-90332
NC_012563:2566500:256664425666442567405762Clostridium botulinum A2 str. Kyoto, complete genomeN-acetylmuramoyl-L-alanine amidase1e-89329
NC_012563:2101449:210342221034222104180759Clostridium botulinum A2 str. Kyoto, complete genomeN-acetylmuramoyl-L-alanine amidase5e-87320
NC_012563:2925472:292933029293302930091762Clostridium botulinum A2 str. Kyoto, complete genomebacteriophage endolysin3e-86318
NC_012654:18893:192671926720223957Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceLycA9e-33140
NC_010516:2305110:231001523100152310788774Clostridium botulinum B1 str. Okra, complete genomeN-acetylmuramoyl-L-alanine amidase1e-27123
NC_006582:2944237:2947330294733029483461017Bacillus clausii KSM-K16, complete genomeN-acetylmuramoyl-L-alanine amidase8e-23107
NC_008593:1362218:1365917136591713672121296Clostridium novyi NT, complete genomeN-acetylmuramoyl-L-alanine amidase cwlL precursor (Cellwall hydrolase) (Autolysin)1e-1996.7
NC_008598:21978:381313813138892762Bacillus thuringiensis str. Al Hakam plasmid pALH1, completeN-acetylmuramoyl-L-alanine amidase (endolysin) (cell wall hydrolase)8e-1684.3
NC_021184:4493440:451665445166544517340687Desulfotomaculum gibsoniae DSM 7213, complete genomeN-acetylmuramoyl-L-alanine amidase5e-1581.6
NC_015425:1295261:132561013256101326428819Clostridium botulinum BKT015925 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase-like protein2e-1479.7
NC_013315:1707293:172678317267831727595813Clostridium difficile CD196 chromosome, complete genomeN-acetylmuramoyl-l-alanine amidase3e-1479.3
NC_014328:180482:1848201848201866311812Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative N-acetylmuramoyl-L-alanine amidase5e-1375.1
NC_015873:1241354:125163212516321252201570Megasphaera elsdenii DSM 20460, complete genomeN-acetylmuramoyl-L-alanine amidase CwlB1e-1273.6
NC_015519:2489728:250441425044142505076663Tepidanaerobacter sp. Re1 chromosome, complete genomecell wall hydrolase/autolysin2e-1272.8
NC_013740:1218429:125365712536571254211555Acidaminococcus fermentans DSM 20731, complete genomecell wall hydrolase/autolysin5e-1271.6
NC_015520:3060495:306407430640743064778705Mahella australiensis 50-1 BON chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase2e-1170.1
NC_017068:1852708:187490318749031875460558Selenomonas ruminantium subsp. lactilytica TAM6421, completeputative N-acetylmuramoyl-L-alanine amidase3e-1168.9
NC_007644:1293701:131535413153541316082729Moorella thermoacetica ATCC 39073, complete genomeN-acetylmuramoyl-L-alanine amidase4e-1168.9
NC_010723:3133302:3143492314349231457052214Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC6e-1168.2
NC_016627:2870900:2888618288861828896881071Clostridium clariflavum DSM 19732 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase1e-1067
NC_013316:1081044:1093266109326610953052040Clostridium difficile R20291, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)3e-1065.9
NC_009089:1202261:1214547121454712165862040Clostridium difficile 630, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)4e-1065.5
NC_013316:1081044:1095797109579710978302034Clostridium difficile R20291, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)6e-1065.1
NC_009089:1202261:1217070121707012191032034Clostridium difficile 630, complete genomecell surface protein (putative N-acetylmuramoyl-L-alanine amidase)5e-1065.1
NC_019970:2551607:2572748257274825741781431Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeN-acetylmuramoyl-L-alanine amidase2e-0963.2
NC_018664:1573925:158825715882571589231975Clostridium acidurici 9a chromosome, complete genomeputative cell wall amidase LytH6e-0961.6
NC_016047:2480921:248393824839382484552615Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completeN-acetylmuramoyl-L-alanine amidase2e-0860.1
NC_016077:1944000:196049419604941961051558Acidaminococcus intestini RyC-MR95 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase2e-0860.1
NC_015555:2259500:2300952230095223023821431Thermoanaerobacterium xylanolyticum LX-11 chromosome, completeN-acetylmuramoyl-L-alanine amidase2e-0859.7
NC_000964:3658000:3658149365814936596391491Bacillus subtilis subsp. subtilis str. 168, complete genomeN-acetylmuramoyl-L-alanine amidase (major autolysin) (CWBP49)2e-0859.7
NC_014209:1910109:191010919101091910789681Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,N-acetylmuramoyl-L-alanine amidase CwlD2e-0859.7
NC_015690:7785875:783284178328417833806966Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein3e-0859.3
NC_018515:3411276:341942134194213420176756Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase4e-0858.9
NC_020291:5981006:5985561598556159878882328Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeN-acetylmuramoyl-L-alanine amidase4e-0858.9
NC_020410:1781884:178188417818841782642759Bacillus amyloliquefaciens subsp. plantarum UCMB5036 completeSporulation-specific N-acetylmuramoyl-L-alanine amidase4e-0858.9
NC_010723:3133302:3141134314113431431912058Clostridium botulinum E3 str. Alaska E43, complete genomesurface protein PspC5e-0858.5
NC_015589:1630461:163505816350581635783726Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase7e-0858.2
NC_013406:781308:801375801375802103729Paenibacillus sp. Y412MC10 chromosome, complete genomecell wall hydrolase/autolysin2e-0757
NC_010321:2276000:2286293228629322895623270Thermoanaerobacter pseudethanolicus ATCC 33223 chromosome, completepeptidoglycan binding domain-containing protein3e-0756.2
NC_008148:2290806:2308321230832123093971077Rubrobacter xylanophilus DSM 9941, complete genomecell wall hydrolase/autolysin3e-0755.8
NC_017208:108134:149586149586150299714Bacillus thuringiensis serovar chinensis CT-43 chromosome, completespore-specific N-acetylmuramoyl-L-alanine amidase3e-0755.8
NC_014171:109280:147537147537148250714Bacillus thuringiensis BMB171 chromosome, complete genomespore-specific N-acetylmuramoyl-L-alanine amidase3e-0755.8
NC_018515:4660808:466437946643794665224846Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase4e-0755.8
NC_013406:781308:794395794395794874480Paenibacillus sp. Y412MC10 chromosome, complete genomepeptidoglycan-binding domain 1 protein6e-0755.1
NC_016593:1466226:1471822147182214729911170Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeerfK/YbiS/YcfS/YnhG protein5e-0755.1
NC_016584:3645245:364620336462033646874672Desulfosporosinus orientis DSM 765 chromosome, complete genomecell wall-associated hydrolase7e-0754.7
NC_006270:3418097:3431919343191934329981080Bacillus licheniformis ATCC 14580, complete genomeN-acetylmuramoyl-L-alanine amidase7e-0754.7
NC_006322:3418268:3432091343209134331701080Bacillus licheniformis ATCC 14580, complete genomeBlyA7e-0754.7
NC_019970:439969:455935455935456609675Thermoanaerobacterium thermosaccharolyticum M0795, complete genomeN-acetylmuramoyl-L-alanine amidase CwlD8e-0754.7
NC_017068:2661419:266645426664542667209756Selenomonas ruminantium subsp. lactilytica TAM6421, completehypothetical protein1e-0654.3
NC_016048:1438721:147035414703541470926573Oscillibacter valericigenes Sjm18-20, complete genomeputative N-acetylmuramoyl-L-alanine amidase2e-0653.5
NC_014538:2158131:2158131215813121614003270Thermoanaerobacter sp. X513 chromosome, complete genomePeptidoglycan-binding domain 1 protein2e-0653.1
NC_009922:2721343:275148627514862752082597Alkaliphilus oremlandii OhILAs, complete genomePeptidoglycan-binding domain 1 protein2e-0653.1
NC_009328:2905000:292383329238332924537705Geobacillus thermodenitrificans NG80-2 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase2e-0653.1
NC_008555:1204000:124123212412321242194963Listeria welshimeri serovar 6b str. SLCC5334, complete genomephage lysin, putative3e-0652.4
UCMB5137:1375622:137628713762871377051765Bacillus atrophaeus UCMB-5137N-acetylmuramoyl-L-alanine amidase4e-0652.4
NC_009674:1707944:171290717129071713650744Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeN-acetylmuramoyl-L-alanine amidase4e-0652
NC_019978:686362:688393688393689076684Halobacteroides halobius DSM 5150, complete genomeN-acetylmuramoyl-L-alanine amidase6e-0651.6
NC_010001:3421710:344030134403013440876576Clostridium phytofermentans ISDg, complete genomecell wall hydrolase/autolysin7e-0651.2