Pre_GI: BLASTP Hits

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Query: NC_012658:2393427:2410751 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2410751, End: 2412442, Length: 1692

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2466000:2483195248319524848861692Clostridium botulinum A2 str. Kyoto, complete genomebenzoyl-CoA reductase, subunit A01121
NC_010516:2374000:2391090239109023927841695Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase subunit/putative R-2-hydroxyglutaryl-CoA dehydratase activase01081
NC_009697:2265409:2283125228312522848191695Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit/ R-2-hydroxyglutaryl-CoA dehydratase activase01080
NC_007503:1047577:1054611105461110562631653Carboxydothermus hydrogenoformans Z-2901, complete genomeputative CoA dehydratase subunit/(R)-2-hydroxyglutaryl-CoA dehydratase activator4e-145515
NC_011832:1148859:117832011783201179126807Candidatus Methanosphaerula palustris E1-9c, complete genomeCoA-substrate-specific enzyme activase3e-66253
NC_009699:3581376:359145035914503592244795Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase activator9e-64244
NC_010516:3545017:355872635587263559520795Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase activator9e-64244
NC_012563:3729817:373987437398743740668795Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase activator2e-63244
NC_009697:3463736:347380634738063474600795Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase activator3e-63243
NC_009698:3359766:337091433709143371708795Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase activator3e-63243
NC_013315:435599:443065443065443874810Clostridium difficile CD196 chromosome, complete genomeactivator of 2-hydroxyisocaproyl-CoA dehydratase2e-55217
NC_017179:446564:452637452637453437801Clostridium difficile BI1, complete genomeactivator of 2-hydroxyisocaproyl-CoA dehydratase2e-55217
NC_003454:822804:832898832898833695798Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completeActivator of (R)-2-hydroxyglutaryl-CoA dehydratase1e-51204
NC_009943:1043210:104577010457701046591822Candidatus Desulfococcus oleovorans Hxd3, complete genomeputative CoA-substrate-specific enzyme activase2e-49197
NC_010520:3526883:352971535297153530473759Clostridium botulinum A3 str. Loch Maree, complete genomeputative CoA-substrate-specific enzyme activase7e-49195
NC_012658:2393427:239804723980472398820774Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative CoA-substrate-specific enzyme activase8e-48192
NC_010516:2374000:237800923780092378782774Clostridium botulinum B1 str. Okra, complete genome2-hydroxyglutaryl-CoA dehydratase component A8e-48192
NC_012563:2466000:246994924699492470722774Clostridium botulinum A2 str. Kyoto, complete genome2-hydroxyglutaryl-CoA dehydratase component A2e-47191
NC_009697:2265409:227002622700262270799774Clostridium botulinum A str. ATCC 19397 chromosome, complete2-hydroxyglutaryl-CoA dehydratase subunit A1e-47191
NC_009698:2265475:227009222700922270865774Clostridium botulinum A str. Hall chromosome, complete genome2-hydroxyglutaryl-CoA dehydratase1e-47191
NC_010337:147664:177486177486178340855Heliobacterium modesticaldum Ice1, complete genomeactivator of (r)-2-hydroxyglutaryl-coa dehydratase domain protein3e-44179
NC_015589:2846000:286744428674442868220777Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-43178
NC_019908:2401577:2401577240157724026471071Brachyspira pilosicoli P43/6/78 chromosome, complete genomeCoA-substrate-specific enzyme activase6e-41169
NC_013887:189400:192714192714193445732Methanocaldococcus sp. FS406-22 chromosome, complete genomeCoA-substrate-specific enzyme activase4e-40166
NC_014828:2038692:208228120822812083090810Ethanoligenens harbinense YUAN-3 chromosome, complete genomeCoA-substrate-specific enzyme activase5e-40166
NC_015562:1189111:121368012136801214414735Methanotorris igneus Kol 5 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-38161
NC_015425:2528549:256470925647092565647939Clostridium botulinum BKT015925 chromosome, complete genomeputative CoA-substrate-specific enzyme activase2e-35150
NC_007519:64157:819938199382772780Desulfovibrio alaskensis G20 chromosome, complete genomeCoA enzyme activase2e-34147
NC_010718:128423:128423128423129397975Natranaerobius thermophilus JW/NM-WN-LF, complete genomeCoA-substrate-specific enzyme activase1e-33145
NC_016584:1436710:145659314565931457555963Desulfosporosinus orientis DSM 765 chromosome, complete genomeCoA-substrate-specific enzyme activase7e-33142
NC_021182:4088000:410867741086774109630954Clostridium pasteurianum BC1, complete genomeCoA-substrate-specific enzyme activase, putative5e-32139
NC_010516:3466000:347106934710693472043975Clostridium botulinum B1 str. Okra, complete genomeputative CoA-substrate-specific enzyme activase4e-31136
NC_009698:3275839:327583932758393276813975Clostridium botulinum A str. Hall chromosome, complete genomeCoA-substrate-specific enzyme activase4e-31136
NC_018515:4442500:444366244436624444450789Desulfosporosinus meridiei DSM 13257 chromosome, complete genomeCoA-substrate-specific enzyme activase6e-29129
NC_014377:1227850:122938612293861230357972Thermosediminibacter oceani DSM 16646 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-27125
NC_011830:633195:6391766391766402791104Desulfitobacterium hafniense DCB-2, complete genomeCoA-substrate-specific enzyme activase1e-27125
NC_016627:3815690:383284638328463833625780Clostridium clariflavum DSM 19732 chromosome, complete genomeCoA-substrate-specific enzyme activase, putative3e-27123
NC_009483:1779601:1791041179104117941513111Geobacter uraniireducens Rf4 chromosome, complete genomeputative CoA-substrate-specific enzyme activase2e-26120
NC_014314:576465:604657604657605466810Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeCoA-substrate-specific enzyme activase5e-26119
NC_018876:1551155:1551155155115515523961242Methanolobus psychrophilus R15 chromosome, complete genomeBadF/BadG/BcrA/BcrD ATPase4e-25116
NC_014253:1818000:1828187182818718294431257Methanohalobium evestigatum Z-7303 chromosome, complete genomemethanogenesis marker protein 151e-24115
NC_009943:1043210:104658810465881047358771Candidatus Desulfococcus oleovorans Hxd3, complete genomeputative CoA-substrate-specific enzyme activase3e-23110
NC_009012:3653111:366096036609603661730771Clostridium thermocellum ATCC 27405, complete genomeputative CoA-substrate-specific enzyme activase2e-23110
NC_013410:3192836:3192836319283631972874452Fibrobacter succinogenes subsp. succinogenes S85 chromosome,CoA-substrate-specific enzyme activase9e-23108
NC_014926:608894:6294446294446326473204Thermovibrio ammonificans HB-1 chromosome, complete genomeCoA-substrate-specific enzyme activase4e-22106
NC_015578:1430112:1430112143011214345364425Treponema primitia ZAS-2 chromosome, complete genomeCoA enzyme activase6e-22105
NC_009464:3058665:3079639307963930808951257Uncultured methanogenic archaeon RC-I, complete genomeputative 2-hydroxyglutaryl-CoA dehydratase activator, component C (archerase)8e-22105
NC_014484:1690272:1690272169027216947054434Spirochaeta thermophila DSM 6192 chromosome, complete genomehypothetical protein2e-21104
NC_020134:1243122:1240063124006312431493087Clostridium stercorarium subsp. stercorarium DSM 8532, completeCoA-substrate-specific enzyme activase3e-21103
NC_010814:3048441:3088379308837930908232445Geobacter lovleyi SZ, complete genome2e-20101
NC_009922:2323083:2344275234427523485614287Alkaliphilus oremlandii OhILAs, complete genomeputative CoA-substrate-specific enzyme activase9e-2099
NC_013887:90929:115352115352116029678Methanocaldococcus sp. FS406-22 chromosome, complete genomeCoA-substrate-specific enzyme activase9e-2099
NC_015732:2762424:2777720277772027823304611Spirochaeta caldaria DSM 7334 chromosome, complete genomeCoA-substrate-specific enzyme activase1e-1998.6
NC_015275:2712991:2712991271299127172114221Clostridium lentocellum DSM 5427 chromosome, complete genomeCoA-substrate-specific enzyme activase3e-1997.4
NC_021184:569653:5696535696535739394287Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein4e-1996.7
NC_017214:191791:2120042120042167644761Bifidobacterium animalis subsp. lactis BB-12 chromosome, completeActivator of (R)-2-hydroxyglutaryl-CoA dehydratase1e-1895.5
NC_017215:1499179:1519392151939215241524761Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,Activator of (R)-2-hydroxyglutaryl-CoA dehydratase1e-1895.5
NC_017216:1494190:1514403151440315190794677Bifidobacterium animalis subsp. lactis BLC1, complete genomeputative CoA-substrate-specific enzyme activase1e-1895.5
NC_011835:625472:6456876456876503544668Bifidobacterium animalis subsp. lactis AD011 chromosome, completeactivator of 2-hydroxyglutaryl-CoA dehydratase1e-1895.5
NC_016627:3205333:3228073322807332323774305Clostridium clariflavum DSM 19732 chromosome, complete genomehypothetical protein1e-1895.1
NC_017217:1499832:1520045152004515247634719Bifidobacterium animalis subsp. lactis V9 chromosome, completehypothetical protein1e-1895.1
NC_012814:1494331:1514758151475815194764719Bifidobacterium animalis subsp. lactis Bl-04, complete genomehypothetical protein1e-1895.1
NC_012815:1494263:1514476151447615191944719Bifidobacterium animalis subsp. lactis DSM 10140, complete genomehypothetical protein1e-1895.1
NC_013171:342714:3533263533263576004275Anaerococcus prevotii DSM 20548, complete genomeCoA-substrate-specific enzyme activase2e-1894.4
NC_020291:1535402:1557937155793715621694233Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeputative CoA-substrate-specific enzyme activase3e-1894
NC_015574:1676798:1682748168274816839831236Methanobacterium sp. SWAN-1 chromosome, complete genomemethanogenesis marker protein 155e-1893.2
NC_015216:652266:6617006617006629321233Methanobacterium sp. AL-21 chromosome, complete genomemethanogenesis marker protein 153e-1790.5
NC_007681:1157402:1173252117325211745051254Methanosphaera stadtmanae DSM 3091, complete genomepredicted activator of 2-hydroxyglutaryl-CoA dehydratase7e-1789.4
NC_009012:1595498:1613874161387416181754302Clostridium thermocellum ATCC 27405, complete genomeputative CoA-substrate-specific enzyme activase9e-1789
NC_017098:1542284:1577543157754315820184476Spirochaeta africana DSM 8902 chromosome, complete genomeactivator of 2-hydroxyglutaryl-CoA dehydratase2e-1687.8
NC_011145:4365730:4365730436573043699984269Anaeromyxobacter sp. K, complete genomeCoA-substrate-specific enzyme activase8e-1169.3
NC_010003:1746319:1755877175587717603404464Petrotoga mobilis SJ95, complete genomeCoA-substrate-specific enzyme activase2e-1067.8
NC_011832:1148859:1177120117712011783011182Candidatus Methanosphaerula palustris E1-9c, complete genome2-hydroxyglutaryl-CoA dehydratase D-component4e-0653.5