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Query: NC_012658:2393427:2408104 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2408104, End: 2408925, Length: 822

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2466000:248069924806992481520822Clostridium botulinum A2 str. Kyoto, complete genomeiron-sulfur cluster-binding protein2e-148524
NC_010516:2374000:238843523884352389256822Clostridium botulinum B1 str. Okra, complete genomeiron-sulfur cluster-binding protein1e-135482
NC_009697:2265409:228047822804782281299822Clostridium botulinum A str. ATCC 19397 chromosome, complete(Fe-S)-binding protein4e-132470
NC_014330:768232:785719785719786549831Brachyspira pilosicoli 95/1000 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein2e-71269
NC_018607:2111581:212874221287422129572831Brachyspira pilosicoli B2904 chromosome, complete genome4Fe-4S ferredoxin6e-71267
NC_015160:2418317:243245124324512433272822Odoribacter splanchnicus DSM 20712 chromosome, complete genome4Fe-4S iron-sulfur binding protein (ferredoxin)3e-54211
NC_013517:3997448:399923439992344000064831Sebaldella termitidis ATCC 33386, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein3e-37155
NC_009483:739010:749601749601750401801Geobacter uraniireducens Rf4 chromosome, complete genome4Fe-4S ferredoxin1e-34147
NC_010814:3048441:304993030499303050733804Geobacter lovleyi SZ, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein7e-34144
NC_012881:964823:985502985502986302801Desulfovibrio salexigens DSM 2638, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein6e-34144
NC_014972:3604534:361645936164593617190732Desulfobulbus propionicus DSM 2032 chromosome, complete genome4Fe-4S ferredoxin iron-sulfur-binding domain-containing protein5e-33141
NC_014844:1270618:131352413135241314324801Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeputative ferredoxin1e-32139
NC_016048:1930089:193070619307061931494789Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-23110
NC_006347:3638165:363980336398033640639837Bacteroides fragilis YCH46, complete genomeputative ferredoxin6e-23107
NC_013173:1231213:124573212457321246547816Desulfomicrobium baculatum DSM 4028, complete genome4Fe-4S ferredoxin iron-sulfur binding domain protein1e-22107
NC_010520:35845:380553805538840786Clostridium botulinum A3 str. Loch Maree, complete genomeiron-sulfur cluster-binding protein4e-0755.5
NC_017297:33519:392713927140059789Clostridium botulinum F str. 230613 chromosome, complete genomeiron-sulfur cluster-binding protein8e-0651.2
NC_009699:33452:392033920339991789Clostridium botulinum F str. Langeland chromosome, complete genome(Fe-S)-binding protein8e-0651.2