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Query: NC_012658:2393427:2404854 Clostridium botulinum Ba4 str. 657 chromosome, complete genome

Start: 2404854, End: 2406086, Length: 1233

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum Ba4 str. 657 was isolated from an infant botulism case in 1976. The strain is a bivalent Ba strain, that simultaneously produces two different toxin types. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010516:2374000:2385338238533823865701233Clostridium botulinum B1 str. Okra, complete genomeputative R-2-hydroxyglutaryl-CoA dehydratase, alpha subunit0796
NC_012563:2466000:2477449247744924786811233Clostridium botulinum A2 str. Kyoto, complete genome(R)-2-hydroxyglutaryl-CoA dehydratase, alpha subunit family0795
NC_009698:2265475:2277291227729122785231233Clostridium botulinum A str. Hall chromosome, complete genomeR-2-hydroxyglutaryl-CoA dehydratase subunit alpha0795
NC_009697:2265409:2277225227722522784571233Clostridium botulinum A str. ATCC 19397 chromosome, completeR-2-hydroxyglutaryl-CoA dehydratase subunit alpha0795
NC_013315:435599:4438834438834451151233Clostridium difficile CD196 chromosome, complete genomesubunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase0664
NC_017179:446564:4534524534524546781227Clostridium difficile BI1, complete genomeoxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase subunit0662
NC_012563:3729817:3738646373864637398691224Clostridium botulinum A2 str. Kyoto, complete genomeR-phenyllactate dehydratase, B subunit5e-110398
NC_009699:3581376:3590222359022235914451224Clostridium botulinum F str. Langeland chromosome, complete genomeR-phenyllactate dehydratase subunit B4e-110398
NC_009697:3463736:3472578347257834738011224Clostridium botulinum A str. ATCC 19397 chromosome, completeR-phenyllactate dehydratase subunit B3e-110398
NC_009698:3359766:3369686336968633709091224Clostridium botulinum A str. Hall chromosome, complete genomeR-phenyllactate dehydratase subunit B3e-110398
NC_010516:3545017:3557498355749835587211224Clostridium botulinum B1 str. Okra, complete genomeR-phenyllactate dehydratase, B subunit3e-110398
NC_003454:822804:8337588337588350861329Fusobacterium nucleatum subsp. nucleatum ATCC 25586, complete(R)-2-hydroxyglutaryl-CoA dehydratase alpha-subunit3e-87322
NC_007503:1047577:1053400105340010546081209Carboxydothermus hydrogenoformans Z-2901, complete genomeputative (R)-2-hydroxyglutaryl-CoA dehydratase, alpha subunit5e-1065.9