Pre_GI: BLASTP Hits

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Query: NC_012656:67949:97993 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Start: 97993, End: 98574, Length: 582

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017203:73952:773067730677881576Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein1e-85315
NC_016792:143614:157848157848158423576Bacillus cereus NC7401 plasmid pNCcld, complete sequencehypothetical protein1e-83308
NC_011777:100631:113892113892114467576Bacillus cereus AH820 plasmid pAH820_272, complete sequencehypothetical protein1e-83308
NC_005707:12735:194301943020005576Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencehypothetical protein1e-83308
NC_011655:88336:102642102642103145504Bacillus cereus AH187 plasmid pAH187_270, complete sequencehypothetical protein2e-77288