Pre_GI: BLASTP Hits

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Query: NC_012656:67949:95772 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Start: 95772, End: 96227, Length: 456

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011777:100631:1116681116681138752208Bacillus cereus AH820 plasmid pAH820_272, complete sequencepeptidase, M23/M37 family protein4e-49193
NC_011655:88336:1003461003461025532208Bacillus cereus AH187 plasmid pAH187_270, complete sequencepeptidase, M23/M37 family protein4e-49193
NC_005707:12735:2002220022222292208Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencepeptidase, M23/M37 family protein4e-49193
NC_012473:46000:8280082800850042205Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencepeptidase, M23/M37 family protein3e-47187
NC_016792:143614:1558011558011578312031Bacillus cereus NC7401 plasmid pNCcld, complete sequencehypothetical protein9e-36148