Pre_GI: BLASTP Hits

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Query: NC_012656:67949:87573 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Start: 87573, End: 87758, Length: 186

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014331:57769:876048760487801198Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completehypothetical protein9e-29125
NC_007322:57710:872978729787494198Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein9e-29125
NC_012579:72715:876298762987814186Bacillus anthracis str. CDC 684 plasmid pX01, complete sequencehypothetical protein1e-28125
NC_005707:12735:302413024130429189Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencehypothetical protein7e-25112
NC_016792:143614:144746144746144934189Bacillus cereus NC7401 plasmid pNCcld, complete sequencehypothetical protein3e-24110
NC_011655:88336:894688946889656189Bacillus cereus AH187 plasmid pAH187_270, complete sequencehypothetical protein3e-24110
NC_017203:73952:986369863698821186Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein8e-24108
NC_011777:100631:103394103394103657264Bacillus cereus AH820 plasmid pAH820_272, complete sequencehypothetical protein6e-23105
NC_012473:46000:745427454274730189Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein6e-1889.7