Pre_GI: BLASTP Hits

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Query: NC_012656:67949:82509 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Start: 82509, End: 82997, Length: 489

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017203:73952:108878108878109501624Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein4e-75279
NC_012579:72715:826348263483041408Bacillus anthracis str. CDC 684 plasmid pX01, complete sequencehypothetical protein3e-63240
NC_007322:57710:823268232682733408Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein3e-63240
NC_014331:57769:826178261783159543Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completeputative inner membrane protein6e-63239
NC_012473:46000:671866718667728543Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein6e-58223
NC_011775:185409:197158197158197802645Bacillus cereus G9842 plasmid pG9842_209, complete sequencehypothetical protein2e-0755.1