Pre_GI: BLASTP Hits

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Query: NC_012656:67949:75809 Bacillus anthracis str. A0248 plasmid pXO1, complete sequence

Start: 75809, End: 76741, Length: 933

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This strain (96-10355; K1256) is a human isolated from USA. This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007322:57710:755457554576477933Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completemembrane protein, putative, (pxo1-60)4e-150530
NC_012579:72715:758537585376785933Bacillus anthracis str. CDC 684 plasmid pX01, complete sequencehypothetical protein7e-150530
NC_014331:57769:755717557176503933Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completemembrane protein3e-149527
NC_017203:73952:111793111793112725933Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,membrane protein2e-145515
NC_012473:46000:601396013961071933Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein5e-145513
NC_011775:185409:188517188517189500984Bacillus cereus G9842 plasmid pG9842_209, complete sequenceconserved membrane protein, putative2e-34146