Pre_GI: BLASTN Hits

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Query: NC_012581:2178000 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 2178000, End: 2200598, Length: 22599

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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Host Information, e.g. soil, Thermo, Russia



Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_014335:20096622009662203256522904Bacillus cereus biovar anthracis str. CI chromosome, complete05894BLASTN svgBLASTP svg
NC_012472:21097192109719213459724879Bacillus cereus 03BB102, complete genome05507BLASTN svgBLASTP svg
NC_020272:43050043050045560725108Bacillus amyloliquefaciens IT-45, complete genome2e-56228BLASTN svgBLASTP svg