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Query: NC_012581:466798:479760 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 479760, End: 480371, Length: 612

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016771:2039195:2043285204328520483005016Bacillus cereus NC7401, complete genomeprophage LambdaBa02, tape measure protein5e-119426
NC_011658:2080390:2084480208448020894955016Bacillus cereus AH187 chromosome, complete genomeputative prophage LambdaBa02, tape measure protein5e-119426
NC_012659:3724729:375834737583473758958612Bacillus anthracis str. A0248, complete genome1e-117421
NC_003997:3724702:375832037583203758931612Bacillus anthracis str. Ames, complete genomehypothetical protein1e-117421
NC_005945:3747652:375882037588203759431612Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-117421
NC_007530:3749645:375844737584473759058612Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-117421
NC_009674:2678932:2687249268724926912894041Bacillus cytotoxicus NVH 391-98 chromosome, complete genomeTP901 family phage tail tape measure protein3e-34144