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Query: NC_012581:466798:474789 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 474789, End: 475199, Length: 411

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_005945:3747652:376399137639913764437447Bacillus anthracis str. Sterne, complete genomehypothetical protein1e-74278
NC_012659:3724729:376351837635183763928411Bacillus anthracis str. A0248, complete genomehypothetical protein1e-74277
NC_007530:3749645:376361837636183764028411Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein1e-74277
NC_003997:3724702:376349137634913763901411Bacillus anthracis str. Ames, complete genomehypothetical protein1e-74277
NC_016771:2039195:204271620427162043111396Bacillus cereus NC7401, complete genomehypothetical protein4e-51199
NC_011658:2080390:208391120839112084306396Bacillus cereus AH187 chromosome, complete genomehypothetical protein4e-51199
NC_011773:4141765:415551141555114155900390Bacillus cereus AH820 chromosome, complete genomehypothetical protein3e-1787.4
NC_014479:1961692:197025419702541970598345Bacillus subtilis subsp. spizizenii str. W23 chromosome, completehypothetical protein3e-0857