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Query: NC_012581:466798:472741 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 472741, End: 473016, Length: 276

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_003997:3724702:376567437656743765949276Bacillus anthracis str. Ames, complete genomehypothetical protein5e-45179
NC_005945:3747652:376617437661743766449276Bacillus anthracis str. Sterne, complete genomehypothetical protein5e-45179
NC_007530:3749645:376580137658013766076276Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-45179
NC_016771:2039195:204066820406682040943276Bacillus cereus NC7401, complete genomehypothetical protein1e-44177
NC_011658:2080390:208186320818632082138276Bacillus cereus AH187 chromosome, complete genomehypothetical protein1e-44177
NC_015690:1186545:121703212170321217343312Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein9e-1062.4
NC_016935:1636278:166649316664931666804312Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein4e-0960.1
NC_006270:1511000:152120215212021521441240Bacillus licheniformis ATCC 14580, complete genomephage related protein3e-0753.9
NC_006322:1507411:152206315220631522302240Bacillus licheniformis ATCC 14580, complete genomehypothetical protein3e-0753.9