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Query: NC_012581:466798:472532 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 472532, End: 472732, Length: 201

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007530:3749645:376608537660853766285201Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-29127
NC_006270:1511000:152070215207021521199498Bacillus licheniformis ATCC 14580, complete genomephage related protein2e-0961.2
NC_006322:1507411:152156315215631522060498Bacillus licheniformis ATCC 14580, complete genomehypothetical protein2e-0961.2
NC_020995:3252500:3272174327217432735561383Enterococcus casseliflavus EC20, complete genomehypothetical protein3e-0960.5
NC_003030:2023751:203883120388312039115285Clostridium acetobutylicum ATCC 824, complete genome1e-0858.2
NC_015687:2025345:204042520404252040709285Clostridium acetobutylicum DSM 1731 chromosome, complete genome1e-0858.2
NC_014623:3503218:3511220351122035144263207Stigmatella aurantiaca DW4/3-1 chromosome, complete genomealpha amylase, catalytic domain subfamily5e-0753.1