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Query: NC_012581:466798:466798 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 466798, End: 467013, Length: 216

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_006270:1511000:151496015149601515298339Bacillus licheniformis ATCC 14580, complete genomephage related protein2e-1064.3
NC_012658:1405788:141238914123891412694306Clostridium botulinum Ba4 str. 657 chromosome, complete genomeGp54 protein6e-0856.2
NC_021182:338428:339985339985340311327Clostridium pasteurianum BC1, complete genomehypothetical protein3e-0753.9
NC_019892:5613436:562873356287335629104372Singulisphaera acidiphila DSM 18658 chromosome, complete genomeHNH endonuclease2e-0651.2
UCMB5137:120656:131475131475131843369Bacillus atrophaeus UCMB-5137prophage Lp3 protein 125e-0649.7
NC_016935:1636278:165982416598241660165342Paenibacillus mucilaginosus 3016 chromosome, complete genomeelectron transporter7e-0649.3