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Query: NC_012581:4478036:4497444 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4497444, End: 4498241, Length: 798

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:449592044959204496717798Bacillus anthracis str. A0248, complete genomeaminoglycoside phosphotransferase family protein1e-141502
NC_011773:4541306:455931945593194560116798Bacillus cereus AH820 chromosome, complete genomeaminoglycoside phosphotransferase family protein1e-141502
NC_003997:4473973:449589344958934496684792Bacillus anthracis str. Ames, complete genomeaminoglycoside phosphotransferase family protein4e-140497
NC_007530:4474000:449602044960204496811792Bacillus anthracis str. 'Ames Ancestor', complete genomeaminoglycoside phosphotransferase family protein4e-140497
NC_017208:4662500:468039346803934681190798Bacillus thuringiensis serovar chinensis CT-43 chromosome, completeputative choline kinase involved in lipopolysaccharide biosynthesis1e-139495
NC_014335:4414052:442982544298254430616792Bacillus cereus biovar anthracis str. CI chromosome, completeaminoglycoside phosphotransferase family protein3e-139494
NC_011772:4606000:462536346253634626160798Bacillus cereus G9842, complete genomeaminoglycoside phosphotransferase family protein8e-139493
NC_017342:1462297:148200814820081482808801Staphylococcus aureus subsp. aureus TCH60 chromosome, completekanamycin kinase2e-66252
NC_017353:1235095:123771012377101238504795Staphylococcus lugdunensis N920143, complete genomehypothetical protein1e-65249
NC_007168:1167454:119503611950361195761726Staphylococcus haemolyticus JCSC1435, complete genomehypothetical protein5e-61234
NC_009004:1770497:179264717926471793420774Lactococcus lactis subsp. cremoris MG1363, complete genomeputative kinase9e-36150
NC_008023:1426687:144513614451361445927792Streptococcus pyogenes MGAS2096, complete genomePhosphotransferase enzyme family4e-33141
NC_007297:1406796:142679214267921427583792Streptococcus pyogenes MGAS5005, complete genomephosphotransferase enzyme family4e-33141
NC_008021:1401249:142124614212461422037792Streptococcus pyogenes MGAS9429, complete genomephosphotransferase enzyme family4e-33141