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Query: NC_012581:4478036:4497162 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4497162, End: 4497440, Length: 279

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:449563844956384495916279Bacillus anthracis str. A0248, complete genomehypothetical protein5e-40162
NC_011969:4396000:441806844180684418346279Bacillus cereus Q1 chromosome, complete genomehypothetical protein5e-40162
NC_014335:4414052:442954344295434429821279Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein5e-40162
NC_003997:4473973:449561144956114495889279Bacillus anthracis str. Ames, complete genomehypothetical protein5e-40162
NC_007530:4474000:449573844957384496016279Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-40162
NC_011772:4606000:462508146250814625359279Bacillus cereus G9842, complete genomehypothetical protein2e-39160
NC_011773:4541306:455903745590374559315279Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-39160