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Query: NC_012581:4478036:4490152 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4490152, End: 4490496, Length: 345

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:448862844886284488972345Bacillus anthracis str. A0248, complete genomehypothetical protein4e-61233
NC_003997:4473973:448860144886014488945345Bacillus anthracis str. Ames, complete genomehypothetical protein4e-61233
NC_005945:4473790:448929044892904489634345Bacillus anthracis str. Sterne, complete genomehypothetical protein4e-61233
NC_007530:4474000:448872844887284489072345Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein4e-61233
NC_011773:4541306:455215045521504552494345Bacillus cereus AH820 chromosome, complete genomehypothetical protein2e-60230
NC_014335:4414052:442279344227934423137345Bacillus cereus biovar anthracis str. CI chromosome, completehypothetical protein2e-59227
NC_017200:4484399:449911744991174499461345Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein2e-58224
NC_005957:4472800:448380344838034484147345Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-58224
NC_010184:4497473:451360845136084513952345Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein8e-55211
NC_011725:4636521:465243046524304652774345Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-55211
NC_011969:4396000:441123044112304411574345Bacillus cereus Q1 chromosome, complete genomehypothetical protein3e-54210
NC_011772:4606000:461832246183224618666345Bacillus cereus G9842, complete genomehypothetical protein1e-53207
NC_004722:4614442:462815346281534628497345Bacillus cereus ATCC 14579, complete genomehypothetical protein4e-53206
NC_017208:4662500:467335246733524673696345Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein7e-53205