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Query: NC_012581:4478036:4481978 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4481978, End: 4482382, Length: 405

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:448048144804814480885405Bacillus anthracis str. A0248, complete genomehypothetical protein2e-73273
NC_003997:4473973:448045444804544480858405Bacillus anthracis str. Ames, complete genomehypothetical protein2e-73273
NC_007530:4474000:448058144805814480985405Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein2e-73273
NC_005945:4473790:448114344811434481547405Bacillus anthracis str. Sterne, complete genomehypothetical protein2e-73273
NC_011773:4541306:454308745430874543491405Bacillus cereus AH820 chromosome, complete genomehypothetical protein6e-72268
NC_005957:4472800:447458144745814474985405Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein1e-70264
NC_017200:4484399:448971844897184490122405Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein4e-67252
NC_004722:4614442:461839246183924618796405Bacillus cereus ATCC 14579, complete genomehypothetical protein6e-65245
NC_017208:4662500:466251346625134662917405Bacillus thuringiensis serovar chinensis CT-43 chromosome, completehypothetical protein9e-65244
NC_011969:4396000:440252044025204402924405Bacillus cereus Q1 chromosome, complete genomehypothetical protein3e-64243
NC_011725:4636521:464276046427604643164405Bacillus cereus B4264 chromosome, complete genomegroup-specific protein4e-64243
NC_010184:4497473:450281145028114503215405Bacillus weihenstephanensis KBAB4, complete genomehypothetical protein4e-64242
NC_011772:4606000:460729846072984607702405Bacillus cereus G9842, complete genomegroup-specific protein6e-63238