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Query: NC_012581:4478036:4481352 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4481352, End: 4481783, Length: 432

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:447985244798524480286435Bacillus anthracis str. A0248, complete genomeputative lipoprotein2e-59226
NC_003997:4473973:447982544798254480259435Bacillus anthracis str. Ames, complete genomelipoprotein, putative2e-59226
NC_005945:4473790:448051444805144480948435Bacillus anthracis str. Sterne, complete genomelipoprotein, putative2e-59226
NC_007530:4474000:447995244799524480386435Bacillus anthracis str. 'Ames Ancestor', complete genomelipoprotein, putative2e-59226
NC_011773:4541306:454245845424584542892435Bacillus cereus AH820 chromosome, complete genomeputative lipoprotein6e-59225
NC_005957:4472800:447395244739524474386435Bacillus thuringiensis serovar konkukian str. 97-27, completehypothetical protein7e-59225
NC_004722:4614442:461776346177634618197435Bacillus cereus ATCC 14579, complete genomehypothetical protein5e-52202