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Query: NC_012581:4478036:4479496 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4479496, End: 4480008, Length: 513

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017200:4484399:448786944878694488381513Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein9e-61232
NC_012659:4474000:447800044780004478512513Bacillus anthracis str. A0248, complete genomehypothetical protein9e-61232
NC_011969:4396000:440047944004794400991513Bacillus cereus Q1 chromosome, complete genomehypothetical protein9e-61232
NC_003997:4473973:447797344779734478485513Bacillus anthracis str. Ames, complete genomehypothetical protein9e-61232
NC_007530:4474000:447810044781004478612513Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein9e-61232
NC_005945:4473790:447866244786624479174513Bacillus anthracis str. Sterne, complete genomehypothetical protein9e-61232
NC_010184:4497473:450076945007694501278510Bacillus weihenstephanensis KBAB4, complete genomeprotein of unknown function DUF9481e-59228
NC_011725:4636521:464071946407194641231513Bacillus cereus B4264 chromosome, complete genomehypothetical protein9e-59225
NC_004722:4614442:461590846159084616420513Bacillus cereus ATCC 14579, complete genomeGeneral stress protein9e-59225
NC_017353:1235095:124863712486371249107471Staphylococcus lugdunensis N920143, complete genomehypothetical protein1e-22105
NC_014915:2900209:292016529201652920578414Geobacillus sp. Y412MC52 chromosome, complete genomeprotein of unknown function DUF9485e-1167
NC_013411:681907:683357683357683770414Geobacillus sp. Y412MC61, complete genomeprotein of unknown function DUF9485e-1167