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Query: NC_012581:4478036:4478036 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 4478036, End: 4479052, Length: 1017

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:4474000:4476540447654044775561017Bacillus anthracis str. A0248, complete genomeputative lipoprotein0686
NC_003997:4473973:4476513447651344775291017Bacillus anthracis str. Ames, complete genomelipoprotein, putative0686
NC_005945:4473790:4477202447720244782181017Bacillus anthracis str. Sterne, complete genomelipoprotein, putative0686
NC_007530:4474000:4476640447664044776561017Bacillus anthracis str. 'Ames Ancestor', complete genomelipoprotein, putative0686
NC_017200:4484399:4486409448640944874251017Bacillus thuringiensis serovar finitimus YBT-020 chromosome,lipoprotein0659
NC_011969:4396000:4399019439901944000351017Bacillus cereus Q1 chromosome, complete genomelipoprotein0656
NC_011725:4636521:4639253463925346402751023Bacillus cereus B4264 chromosome, complete genomelipoprotein0633
NC_004722:4614442:4614442461444246154641023Bacillus cereus ATCC 14579, complete genomeSex pheromone staph-cAM373 precursor0633
NC_010184:4497473:4499310449931045003261017Bacillus weihenstephanensis KBAB4, complete genomeCamS sex pheromone cAM373 family protein1e-163576
NC_016779:312500:3176563176563188491194Bacillus cereus F837/76 chromosome, complete genomePutative pheromone precursor lipoprotein5e-46185
NC_017200:345502:3497933497933509951203Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein4e-45181
NC_021171:358456:3668243668243679961173Bacillus sp. 1NLA3E, complete genomehypothetical protein1e-43177
NC_015660:3518931:3558838355883835600011164Geobacillus thermoglucosidasius C56-YS93 chromosome, completeCamS sex pheromone cAM373 family protein9e-41167
NC_006270:718169:7224417224417236311191Bacillus licheniformis ATCC 14580, complete genomeYerH2e-37156
NC_006322:717953:7222257222257234151191Bacillus licheniformis ATCC 14580, complete genomeYerH2e-37156
NC_017347:2017097:2024008202400820252071200Staphylococcus aureus subsp. aureus T0131 chromosome, completePheromone lipoprotein CamS1e-25117
NC_008497:1575884:1596262159626215974071146Lactobacillus brevis ATCC 367, complete genomehypothetical protein1e-23110
NC_007929:1397989:1399906139990614010511146Lactobacillus salivarius subsp. salivarius UCC118, complete genomeLipoprotein, pheromone precursor9e-22104
NC_015278:1960774:1977083197708319782191137Aerococcus urinae ACS-120-V-Col10a chromosome, complete genomeCamS sex pheromone family protein3e-1582.8