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Query: NC_012581:1505276:1521114 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 1521114, End: 1521266, Length: 153

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012659:2715651:271732427173242717476153Bacillus anthracis str. A0248, complete genome4e-21100
NC_011773:2782465:2782465278246527851312667Bacillus cereus AH820 chromosome, complete genomehypothetical protein3e-1683.6
NC_003909:2798622:2798622279862228017383117Bacillus cereus ATCC 10987, complete genomemembrane protein, MmpL family, putative8e-1579
NC_014335:2718000:2719357271935727224733117Bacillus cereus biovar anthracis str. CI chromosome, completemembrane protein4e-1683.6
NC_006274:2779380:2780666278066627837913126Bacillus cereus E33L, complete genomeconserved hypothetical protein; two MmpL domains8e-1579
NC_016779:2693790:2693790269379026969063117Bacillus cereus F837/76 chromosome, complete genomemembrane protein, MmpL family4e-1683.6
NC_011772:2860000:2862262286226228653783117Bacillus cereus G9842, complete genomemembrane protein, MmpL family4e-1476.6
NC_011969:2706000:2707523270752327106393117Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-1478.6
NC_017208:2942554:2944492294449229476083117Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePhage infection protein3e-1373.6
NC_005957:2756000:2756118275611827592433126Bacillus thuringiensis serovar konkukian str. 97-27, completemembrane protein, MmpL family4e-1683.6
NC_008600:2792584:2792584279258427957093126Bacillus thuringiensis str. Al Hakam, complete genomemembrane protein, MmpL family4e-1683.6