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Query: NC_012581:1075663:1097032 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 1097032, End: 1097427, Length: 396

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011969:3106500:311751231175123117889378Bacillus cereus Q1 chromosome, complete genomehypothetical protein1e-63241
NC_016771:3097173:310950931095093109886378Bacillus cereus NC7401, complete genomelipoprotein1e-63241
NC_011725:3231859:324473432447343245114381Bacillus cereus B4264 chromosome, complete genomelipoprotein2e-63240
NC_004722:3303264:331613933161393316516378Bacillus cereus ATCC 14579, complete genomehypothetical protein4e-62236
NC_011772:3259483:327254432725443272945402Bacillus cereus G9842, complete genomegroup-specific protein2e-61233
NC_017200:3221508:323378432337843234161378Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein3e-61233
NC_011658:3144000:315544631554463155727282Bacillus cereus AH187 chromosome, complete genomeputative lipoprotein1e-46184