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Query: NC_012581:1075663:1096716 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 1096716, End: 1096955, Length: 240

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016771:3097173:310996331099633110202240Bacillus cereus NC7401, complete genomehypothetical protein8e-26115
NC_011658:3144000:315580431558043156043240Bacillus cereus AH187 chromosome, complete genomehypothetical protein8e-26115
NC_011969:3106500:311796631179663118205240Bacillus cereus Q1 chromosome, complete genomehypothetical protein9e-26115
NC_017200:3221508:323423832342383234477240Bacillus thuringiensis serovar finitimus YBT-020 chromosome,hypothetical protein1e-25114
NC_004722:3303264:331659333165933316832240Bacillus cereus ATCC 14579, complete genomehypothetical protein2e-25114
NC_011725:3231859:324523732452373245476240Bacillus cereus B4264 chromosome, complete genomehypothetical protein7e-25112
NC_011772:3259483:327300032730003273227228Bacillus cereus G9842, complete genomehypothetical protein2e-1684.7