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Query: NC_012581:1075663:1095479 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 1095479, End: 1095892, Length: 414

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_016771:3097173:311104831110483111461414Bacillus cereus NC7401, complete genomeATP synthase protein I1e-63241
NC_011969:3106500:311905031190503119463414Bacillus cereus Q1 chromosome, complete genomeATP synthase protein i1e-63241
NC_011658:3144000:315688931568893157302414Bacillus cereus AH187 chromosome, complete genomeputative ATP synthase protein I1e-63241
NC_017200:3221508:323532932353293235742414Bacillus thuringiensis serovar finitimus YBT-020 chromosome,ATP synthase protein I2e-63240
NC_004722:3303264:331770233177023318115414Bacillus cereus ATCC 14579, complete genomeATP synthase protein I4e-63239
NC_011725:3231859:324633032463303246743414Bacillus cereus B4264 chromosome, complete genomeATP synthase I1e-62238
NC_011772:3259483:327407232740723274491420Bacillus cereus G9842, complete genomeputative ATP synthase protein I2e-58223
NC_004193:3078730:309153030915303091919390Oceanobacillus iheyensis HTE831, complete genomeH(+)-transporting ATP synthase i chain5e-0649.7