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Query: NC_012581:1075663:1091000 Bacillus anthracis str. CDC 684 chromosome, complete genome

Start: 1091000, End: 1091176, Length: 177

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011772:3259483:327948932794893279665177Bacillus cereus G9842, complete genomehypothetical protein9e-28122
NC_011283:3379181:338476133847613384988228Klebsiella pneumoniae 342 chromosome, complete genomehypothetical protein8e-1165.9
NC_013850:3340882:334356433435643343791228Klebsiella variicola At-22 chromosome, complete genomeprotein of unknown function DUF12728e-1165.9
NC_016109:3591401:361159736115973611791195Kitasatospora setae KM-6054, complete genomehypothetical protein2e-1064.3
NC_013592:1465015:147023414702341470461228Dickeya dadantii Ech586, complete genomeprotein of unknown function DUF12723e-0960.8